Synthesis[edit]
Synthesis:https://en.wikipedia.org/wiki/Fenethylline#cite_note-57″>[57] Patent:https://en.wikipedia.org/wiki/Fenethylline#cite_note-58″>[58]
Theophylline (1) is alkylated with 2-bromochloroethane [107-04-0] (2) to give 7-(2-Chloroethyl)theophylline (aka Benaphyllin, Eupnophile) [5878-61-5] (3). Displacment of the remaining halogen leaving group by the primary amine in amphetamine [300-62-9] (4) gives fenethylline (5).
…
- Rücker, Gerhard; Neugebauer, Martina; Neugebauer, Michael; Heiden, Paul-G. (1987). “Zur chemischen Stabilität des Fenetyllins”. Archiv der Pharmazie. 320 (12): 1272–1275. doi:10.1002/ardp.198700045.
- ^ Kohlstaedt Dr Erwin, Klingler Dr Karl-Heinz, DE 1123329 (1962 to Chemiewerk Homburg Zweignieder).
So, how tough is this? Not that we’re going to go into business competing with the Syriian government, obviously, we all prefer living much too much for that.
But as a technical matter, how tough is this synthesis?
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