Depression in older adults is often brushed off as a natural part of aging, but that couldn’t be further from the truth. What many people don’t realize is how often food plays a role in these emotional and cognitive shifts. But not just any food — specifically, ultraprocessed food. These are the packaged meals, sweetened drinks, snack bars and frozen options that dominate grocery shelves and restaurant menus.
They’re cheap, convenient and deceptively common, even in diets that seem relatively healthy on the surface. If you’re over 70, your brain is especially sensitive to the effects of these ingredients. Processed foods are more than empty calories. They actively interfere with how your brain communicates, how your body produces energy and how you feel from one day to the next. And if you’re like most people, you’re likely eating more of them than you think.
This matters, because late-life depression isn’t just a personal struggle. It’s a serious condition that drains your energy, disrupts your sleep, dulls your memory and robs you of interest in the things you once enjoyed. Left untreated, it raises your risk for dementia, chronic disease and early death.
It’s become a public health issue that’s widespread, underrecognized and increasingly tied to everyday lifestyle habits, including what’s going into your mouth. Let’s break down what the latest research uncovered about processed food, your mental health and what you can do to protect your mood as you age.
Even Modest Processed Food Intake Raises Depression Risk in Older Adults
Researchers from Monash University in Melbourne, Australia, looked at how eating ultraprocessed foods affects depression risk in people over 70. The study, published in BMC Medicine, reviewed health and diet data from 11,192 older Australian adults. They used a method that mimics a clinical trial to compare people who ate less than four servings of processed food a day with those who ate four or more.
Importantly, researchers followed participants for nearly six years, making this one of the longest and most robust analyses of its kind.
• Eating just four servings of ultraprocessed food per day increased depression risk by 10% — Compared to those who consumed less than four daily servings, people in the high-ultraprocessed food group were significantly more likely to develop depressive symptoms during the follow-up.
Even when the researchers removed those already using antidepressants or with symptoms at baseline, the results didn’t improve — risk rose by 11% in the high-UPF group.
• Mental health scores declined as processed food servings increased — Participants were evaluated using a mental health quality-of-life score. The more processed food they ate, the lower their mental well-being score dropped over time.
Those who ate the most servings of processed food each day had a 0.57-point lower mental health score than those who ate the least. That might sound small, but in population health terms, it’s a measurable and important decline.
• Certain groups were hit harder than others — The drop in mood and mental health was most pronounced in women, people with higher body mass index and those with lower education levels. Interestingly, the association was also stronger among people who didn’t have multiple chronic conditions, suggesting processed food affects mental health even in people who otherwise feel well.
• Portion size and frequency both mattered — Not only did the number of daily servings affect outcomes, but so did the overall quantity of food consumed. Participants who ate the most grams of ultraprocessed food per day, regardless of how often, had a 15% higher risk of developing depressive symptoms compared to those who ate the least. This confirms it’s not just the frequency, but the total load of processed food that matters.
Are Inflammation and Gut Disruption the Root Causes?
Though the study didn’t run lab tests to pinpoint mechanisms, the researchers pointed to multiple likely explanations. Ultraprocessed foods contain refined sugar, artificial additives and oxidized fats, which are known to trigger systemic inflammation. Chronic inflammation is already linked to depression, as it disrupts brain chemistry, stress hormone regulation and sleep.
• Disruption of the gut-brain axis likely plays a role — Ultraprocessed foods damage your gut microbiome — the complex ecosystem of bacteria that communicates with your brain. Additives like emulsifiers and artificial sweeteners damage the protective gut lining and change microbial diversity. These changes impair production of brain-supporting neurotransmitters like dopamine, which plays a role in mood regulation.
• Oxidative stress caused by poor diet damages brain cells — Another proposed mechanism involves oxidative stress, a state where your body can’t neutralize damaging free radicals fast enough. Processed foods contribute to this imbalance by introducing harmful compounds and lacking protective nutrients. Over time, oxidative stress impairs brain signaling, energy metabolism and memory, contributing to a downward spiral in mental health.
Linoleic Acid in Processed Foods Is a Direct Hit to Your Cellular Energy
Linoleic acid (LA), the primary polyunsaturated fat in the vegetable oils common in processed food, doesn’t just sit in your body harmlessly. It goes straight to your mitochondria, the tiny structures inside your cells responsible for producing energy.
These cellular engines generate adenosine triphosphate (ATP), the fuel that powers everything from brain function to hormone balance. When LA builds up, it damages those engines, causing them to slow down or malfunction. That energy shortfall means your cells can’t repair themselves or respond to stress, which opens the door to fatigue, mood changes and disease.
• Your LA intake has skyrocketed compared to previous generations — Since the 1950s, LA consumption in Western diets has exploded. That spike lines up almost exactly with the rise in chronic diseases like obesity, insulin resistance and depression.1
LA is now a primary ingredient in everything from crackers and cookies to sauces and salad dressings, including many “healthy” ones. If you’re eating packaged or restaurant food regularly, you’re likely consuming far more LA than your body was ever designed to handle.
• Your body turns excess LA into toxic byproducts — When you eat foods rich in LA, your body metabolizes it into harmful compounds. These byproducts damage your cells and interfere with insulin signaling, making it harder to regulate your blood sugar. They also trigger your immune system to produce inflammatory chemicals.
This chronic, low-level inflammation silently sabotages your metabolism and increases your risk for mood disorders, weight gain and long-term disease.
• To lower your LA intake, you need to rethink your fats — I recommend keeping your total LA consumption below 5 grams per day, and ideally under 2 grams. To get there, eliminate vegetable oils like soybean, corn, sunflower, safflower, grapeseed and canola.
These are the biggest LA offenders and show up in nearly every processed item on grocery store shelves. Don’t fall for fruit-based oils either. Olive and avocado oils are often cut with cheaper vegetable oils and contain high amounts of monounsaturated fat, which causes similar mitochondrial stress. Stick with healthier fats like grass fed butter, ghee or beef tallow.
• Restaurant meals and poultry products are hidden LA sources — Eating out means giving up control. Most restaurants use vegetable oils to fry or sauté just about everything. Even the sauces and dressings are usually made with LA-heavy oils. If you’re serious about cutting this fat from your life, limit restaurant meals or ask exactly what oils are used in the kitchen.
It’s also smart to cut back on chicken and pork, as the meat is typically high in LA. Grass fed beef and lamb, by contrast, are naturally much lower in this inflammatory fat.
Support Mental Health by Fixing What’s on Your Plate
If your goal is to protect your mood and mental clarity as you age, one of the most powerful steps to take is removing ultraprocessed food. That means no more pretending that a granola bar or “organic” frozen meal is a healthy option.
If you’re eating these highly processed foods daily, it’s undermining your mental health, whether you realize it or not. You don’t need to overhaul your life overnight, but you do need to make steady, smart changes that help your brain work the way it was designed to. Here’s where I recommend starting:
1. Remove LA from your diet — If you only do one thing, make it this. As mentioned, LA is found in nearly all processed foods and restaurant meals. This fat builds up in your tissues and causes mitochondrial stress, which impacts your cellular energy and your brain’s ability to regulate mood.
I recommend swapping vegetable oils for saturated fats like grass fed butter, ghee and tallow. Even olive and avocado oil are problematic, so use them sparingly or not at all. Your target? Keep total LA intake below 5 grams per day and ideally under 2 grams. Use a nutrition tracker to figure out where you are.
2. Shop the perimeter and skip the boxes — Your brain thrives on real food — things your great-grandparents would have recognized. That means fresh fruits and vegetables, root starches, pasture-raised eggs, grass fed meats and homemade broths.
If you’re buying mostly items that don’t need a label — those foods typically found around the perimeter of your grocery store — you’re on the right track. When you do buy packaged items, check for ingredients like “vegetable oil,” “soy lecithin,” “natural flavors” and “high-fructose corn syrup.” Those are red flags that the product is ultraprocessed.
3. Sip smarter to protect your mind — Soft drinks, energy drinks and even plant-based milks contain processed sugars, acids, emulsifiers and artificial sweeteners. Diet versions are also a problem. These drinks disrupt gut bacteria, spike blood sugar and degrade the lining of your intestines, one of the key pathways to depression. Instead, hydrate with filtered water, herbal teas or fresh fruit juice with pulp.
4. Eat to feed your gut, not your cravings — Ultraprocessed foods wipe out the balance of bacteria in your gut that keep your mind stable and focused. On the other hand, healthy carbohydrates play a key role in supporting your mitochondrial function. Glucose, derived from carbohydrates, serves as your cells’ preferred fuel source for energy production. Instead of restricting carbs, focus on eating 250 grams of the right types.
Start slowly introducing whole fruits, well-cooked root vegetables and small amounts of well-tolerated cooked starches. If your gut health is compromised, avoid raw greens, high-fiber grains and beans until your gut is healed.
5. Track what you eat for five days to spot patterns — Most people have no idea how much processed food they’re actually consuming until they see the numbers. I suggest logging your food in an app that shows macronutrients and ingredient lists. Look for patterns: Where is LA hiding? Are you eating more frozen meals than you thought? Once you see it laid out, it’s easier to take control — and easier to cut what’s dragging your mental health down.
You don’t need to overhaul your entire diet in one shot. But you do need to be honest about what’s going in your mouth and how it’s making you feel. Food is either feeding your brain or fighting it. You get to decide which it is.
FAQs About Ultraprocessed Foods and Depression
Q: How much processed food increases depression risk in older adults?
A: Eating just four servings of ultraprocessed food per day raised the risk of developing depressive symptoms by 10%, according to a study of more than 11,000 Australians aged 70 and older. That risk climbed to 11% after adjusting for those already showing symptoms or using antidepressants at the study’s start.
Q: How does processed food affect mental health?
A: Ultraprocessed foods contribute to mitochondrial dysfunction, chronic inflammation, oxidative stress and gut microbiome disruption — all of which impair brain chemistry, hormone balance and neurotransmitter production. These changes are linked to depression and other mood disorders, even in people without existing chronic health conditions.
Q: Why is LA a particular concern in ultraprocessed foods?
A: LA, a polyunsaturated fat found in vegetable oils, accumulates in cell membranes and damages mitochondria, the energy producers in your cells. This mitochondrial dysfunction leads to lower cellular energy, poor brain function and increased risk for depression and chronic illness.
Q: Which foods are highest in LA and should be avoided?
A: Common high-LA sources include vegetable oils such as soybean, corn, canola, sunflower, safflower, grapeseed and many processed or restaurant-prepared foods. Even “healthy” packaged foods and salad dressings often contain these oils. Chicken and pork are also typically high in LA.
Q: What are the most effective dietary changes to support mood as you age?
A: Start by removing vegetable oils and ultraprocessed foods. Focus on eating whole, nutrient-dense foods like grass fed meat, well-cooked root vegetables, fresh fruits and homemade broths. Track your intake for five days to identify hidden processed foods and aim to reduce LA intake below 5 grams daily, ideally under 2 grams.
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